Selected Review on the role and regulation of cytoskeleton in the nervous system:


  • Ahmed, W. W., Rajagopalan, J., Tofangchi, A., Saif, T. A. (2013). Neuromechanics: the role of tension in neuronal growth and memory. In “Nano and Cell Mechanics: Fundamentals and Frontiers” (H. D. Espinosa, G. Bao, Eds.), pp. 35-64. Wiley – LINK
  • Akhmanova, A., and Stearns, T. (2013). EDITORIAL: Cell architecture: putting the building blocks together. Current Opinion in Cell Biology 25, 3-5 – LINK
  • Baas, P. W. (2013). Microtubule stability in the axon: new answers to an old mystery. Neuron 78, 3-5 – LINK
  • Baas, P. W., Ahmad, F. J. (2013). Beyond taxol: microtubule-based treatment of disease and injury of the nervous system. Brain, 10.1093/brain/awt153  – LINK
  • Breitsprecher, D., and Goode, B. L. (2013). Formins at a glance. J Cell Sci 126, 1-7 – LINK
  • Ditlev, J. A., Mayer, B. J., and Loew, L. M. (2013). There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton. Biophys J 104, 520-32 – LINK
  • Ferrier, A., Boyer, J. G., and Kothary, R. (2013). Cellular and molecular biology of neuronal Dystonin. Int Rev Cell Mol Biol 300, 85-120 – LINK
  • Flynn, K. C. (2013). The cytoskeleton and neurite initiation. Bioarchitecture 3 – LINK
  • Franker, M. A., and Hoogenraad, C. C. (2013). Microtubule-based transport – basic mechanisms, traffic rules and role in neurological pathogenesis. J Cell Sci – LINK
  • Franze, K., Janmey, P. A., Guck, J. (2013). Mechanics in neuronal development and repair. Annu Rev Biomed Eng 15, 227-51 – LINK
  • Gallo, G. (2013). Mechanisms underlying the initiation and dynamics of neuronal filopodia: from neurite formation to synaptogenesis. Int Rev Cell Mol Biol 301, 95-156 – LINK
  • Gomez, T. M., Letourneau, P. C. (2013). Actin dynamics in growth cone motility and navigation. J Neurochem  – LINK
  • Millecamps, S., and Julien, J. P. (2013). Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci 14, 161-76 – LINK
  • Prokop, A. (2013). The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance. Neur Dev 8, 17 – LINK
  • Prokop, A., Beaven, R., Qu, Y., and Sánchez-Soriano, N. (2013). Using fly genetics to dissect the cytoskeletal machinery of neurons during axonal growth and maintenance. J. Cell Sci. 126, 1-11 – LINK
  • Schwarz, T. L. (2013). Mitochondrial trafficking in neurons. Cold Spring Harb Perspect Biol 5 – LINK
  • Tedeschi, A., Bradke, F. (2013). The DLK signalling pathway–a double-edged sword in neural development and regeneration. EMBO Rep 14, 605-14 – LINK


  • Adalbert, R., and Coleman, M. P. (2012). Axon pathology in age-related neurodegenerative disorders. Neuropathol Appl NeurobiolLINK
  • Baas, P. W., and Mozgova, O. I. (2012). A novel role for retrograde transport of microtubules in the axon. Cytoskeleton (Hoboken) 69, 416-25 – LINK
  • Bradke, F., Fawcett, J. W., and Spira, M. E. (2012). Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nat Rev Neurosci 13, 183-93 – LINK
  • Fang, Y., and Bonini, N. M. (2012). Axon degeneration and regeneration: insights from Drosophila models of nerve injury. Annu Rev Cell Dev Biol 28, 575-97 – LINK
  • Gistelinck, M., Lambert, J. C., Callaerts, P., Dermaut, B., and Dourlen, P. (2012). Drosophila models of tauopathies: what have we learned? Int J Alzheimers Dis 2012, 970980 – LINK
  • Goellner, B., and Aberle, H. (2012). The synaptic cytoskeleton in development and disease. Dev Neurobiol 72, 111-25 – LINK
  • Goldstein, L. S. (2012). Axonal transport and neurodegenerative disease: can we see the elephant? Prog Neurobiol 99, 186-90 – LINK
  • Himmelstein, D. S., Ward, S. M., Lancia, J. K., Patterson, K. R., and Binder, L. I. (2012). Tau as a therapeutic target in neurodegenerative disease. Pharmacol Ther 136, 8-22 – LINK
  • Jaiswal, M., Sandoval, H., Zhang, K., Bayat, V., and Bellen, H. J. (2012). Probing mechanisms that underlie human neurodegenerative disease in Drosophila. Annu Rev GenetLINK
  • Lancaster, M. A., and Knoblich, J. A. (2012). Spindle orientation in mammalian cerebral cortical development. Curr Opin Neurobiol 22, 737-46 – LINK
  • Nugent, A. A., Kolpak, A. L., and Engle, E. C. (2012). Human disorders of axon guidance. Curr Opin Neurobiol 22, 837-43 – LINK
  • Papanikolopoulou, K., Skoulakis, E. M. (2011). The power and richness of modelling tauopathies in Drosophila. Mol Neurobiol 44, 122-33 – LINK
  • Tuszynski, Mark H., and Steward, O. (2012). Concepts and methods for the study of axonal regeneration in the CNS. Neuron 74, 777-791 – LINK
  • Twelvetrees, A., Hendricks, A. G., and Holzbaur, E. L. (2012). SnapShot: axonal transport. Cell 149, 950-950 e1 – LINK
  • Tyler, W. J. (2012). The mechanobiology of brain function. Nat Rev Neurosci 13, 867-78 – LINK
  • Wang, J. T., Medress, Z. A., and Barres, B. A. (2012). Axon degeneration: molecular mechanisms of a self-destruction pathway. J Cell Biol 196, 7-18 – LINK


  • Baas, P. W., and Lin, S. (2011). Hooks and comets: The story of microtubule polarity orientation in the neuron. Dev Neurobiol 71, 403-18 – LINK
  • Dent, E. W., Gupton, S. L., and Gertler, F. B. (2011a). The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol 3LINK
  • Dent, E. W., Merriam, E. B., and Hu, X. (2011b). The dynamic cytoskeleton: backbone of dendritic spine plasticity. Curr Opin Neurobiol 21, 175-81 – LINK
  • Eschbach, J., and Dupuis, L. (2011). Cytoplasmic dynein in neurodegeneration. Pharmacol Ther 130, 348-63 – LINK
  • Friocourt, G., Marcorelles, P., Saugier-Veber, P., Quille, M. L., Marret, S., and Laquerriere, A. (2011). Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly. Acta Neuropathol 121, 149-70 – LINK
  • Hoogenraad, C. C., and Akhmanova, A. (2011). Dendritic spine plasticity: new regulatory roles of dynamic microtubules. Neuroscientist 16, 650-61 – LINK
  • Janke, C., and Bulinski, J. C. (2011). Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol 12, 773-86 – LINK
  • Morris, M., Maeda, S., Vossel, K., and Mucke, L. (2011). The many faces of tau. Neuron 70, 410-26 – LINK
  • Suter, D. M., and Miller, K. E. (2011). The emerging role of forces in axonal elongation. Prog Neurobiol 94, 91-101 – LINK
  • Tischfield, M. A., Cederquist, G. Y., Gupta, M. L., Jr., and Engle, E. C. (2011). Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations. Curr Opin Genet Dev 21, 286-94 – LINK


  • Fletcher, D. A., and Mullins, R. D. (2010). Cell mechanics and the cytoskeleton. Nature 463, 485-92 – LINK
  • Franze, K., and Guck, J. (2010). The biophysics of neuronal growth. Rep. Prog. Phys. 73, 094601 (19pp) – LINK
  • Hirokawa, N., Niwa, S., and Tanaka, Y. (2010). Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron 68, 610-638 – LINK
  • Iqbal, K., Liu, F., Gong, C. X., and Grundke-Iqbal, I. (2010). Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res 7, 656-64 – LINK
  • Janke, C., and Kneussel, M. (2010). Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. Trends Neurosci 33, 362-72 – LINK


  • Bamburg, J. R., and Bloom, G. S. (2009). Cytoskeletal pathologies of Alzheimer disease. Cell Motil Cytoskeleton 66, 635-49 – LINK
  • Gardiner, J., and Marc, J. (2009). Disruption of normal cytoskeletal dynamics may play a key role in the pathogenesis of epilepsy. Neuroscientist  – LINK
  • Geraldo, S., and Gordon-Weeks, P. R. (2009). Cytoskeletal dynamics in growth-cone steering. J Cell Sci 122, 3595-604 – LINK
  • Giannone, G., Mege, R. M., and Thoumine, O. (2009). Multi-level molecular clutches in motile cell processes. Trends Cell Biol 19, 475-86 – LINK
  • Gozes, I. (2011). Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des 17, 3413-7 – LINK
  • Hoogenraad, C. C., and Bradke, F. (2009). Control of neuronal polarity and plasticity – a renaissance for microtubules? Trends Cell Biol 19, 669-76 – LINK
  • Letourneau, P. C. (2009). Actin in axons: stable scaffolds and dynamic filaments. Results Probl Cell Differ 48, 65-90 – LINK
  • Lowery, L. A., and van Vactor, D. (2009). The trip of the tip: understanding the growth cone machinery. Nat Rev Mol Cell Biol 10, 332-43 – LINK
  • Perrot, R., and Eyer, J. (2009). Neuronal intermediate filaments and neurodegenerative disorders. Brain Res Bull 80, 282-95 – LINK
  • Poulain, F. E., and Sobel, A. (2009). The microtubule network and neuronal morphogenesis: Dynamic and coordinated orchestration through multiple players. Mol Cell Neurosci, doi:10.1016/j.mcn.2009.07.012 – LINK


  • Barth, A. I., Caro-Gonzalez, H. Y., and Nelson, W. J. (2008). Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization. Semin Cell Dev Biol 19, 245-51 – LINK
  • Birbach, A. (2008). Profilin, a multi-modal regulator of neuronal plasticity. Bioessays 30, 994-1002 – LINK
  • Conde, C., and Caceres, A. (2009). Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 10, 319-32 – LINK
  • Drees, F., and Gertler, F. B. (2008). Ena/VASP: proteins at the tip of the nervous system. Curr Opin Neurobiol 18, 53-9 – LINK
  • Goldstein, A. Y., Wang, X., and Schwarz, T. L. (2008). Axonal transport and the delivery of pre-synaptic components. Curr Opin Neurobiol 18, 495-503 – LINK
  • Hirokawa, N., and Noda, Y. (2008). Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics. Physiol Rev 88, 1089-118 – LINK
  • Pak, C. W., Flynn, K. C., and Bamburg, J. R. (2008). Actin-binding proteins take the reins in growth cones. Nat Rev Neurosci 9, 136-47 – LINK
  • Perrot, R., Berges, R., Bocquet, A., and Eyer, J. (2008). Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration. Mol Neurobiol 38, 27-65 – LINK
  • Witte, H., and Bradke, F. (2008). The role of the cytoskeleton during neuronal polarization. Curr Opin Neurobiol 18, 479-87 – LINK


  • Ishikawa, R., and Kohama, K. (2007). Actin-binding proteins in nerve cell growth cones. J Pharmacol Sci 105, 6-11 – LINK
  • Maloney, M. T., and Bamburg, J. R. (2007). Cofilin-mediated neurodegeneration in Alzheimer’s disease and other amyloidopathies. Mol Neurobiol 35, 21-44 – LINK
  • Riederer, B. M. (2007). Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein. Brain Res Bull 71, 541-58 – LINK
  • Salinas, P. C. (2007). Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway. Trends Cell Biol 17, 333-42 – LINK
  • Salinas, S., Carazo-Salas, R. E., Proukakis, C., Schiavo, G., and Warner, T. T. (2007). Spastin and microtubules: Functions in health and disease. J Neurosci Res 85, 2778-82 – LINK
  • Sánchez-Soriano, N., Tear, G., Whitington, P., and Prokop, A. (2007). Drosophila as a genetic and cellular model for studies on axonal growth. Neural Develop 2, 9 – LINK
  • Siegrist, S. E., and Doe, C. Q. (2007). Microtubule-induced cortical cell polarity. Genes Dev 21, 483-96 – LINK
  • Saxena, S., and Caroni, P. (2007). Mechanisms of axon degeneration: from development to disease. Prog Neurobiol 83, 174-91 – LINK

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